BY ABDULMUMINI ADEKU.
Diabetes just like other forms of medical conditions have a
lot of new technological inventions or breakthroughs.
In a lecture recently,The Chief Medical Director of the A.B.
10 Hospital Group ,Ifako Ijaiye,Lagos,Nigeria ,Dr Kunle Akinosho while
lamenting the possible situations that could lead to the ailment urged the
people to watch their intake of carbohydrates into the body .
He listed features of the ailments at a recent lecture as the
following:the importance of insulin,pancreas,islets of langerhans to the human
body.
He showed the audience in attendance at the lecture that
took place at the Redeem Christain Church of God,jesus Parish Embassy Zone in
Ifako Ijaiye ,a media presentation of various forms of hardship faced by
Diabetes conditioned patients at the different stages of life span of the
disease.
He however added that irrespective of what some might term a
hopeless situation ,he was nonetheless happy to tell everyone that there were
several new inventions globally to help tackle the situation.
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RESOURCE MATERIALS ARE ON THE WEB,BUT THE EDITORIAL AND POLICY BOARD OF THE
E.N.M. PAEDIA EXPRESS MULTIMEDIA GROUP OF LAGOS,NIGERIA HAS APROVED THIS FOR
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Published
Researchers may have found a way to replace beta
cells commonly lost in type 1 diabetes.
Diabetes ranks as the seventh leading
cause of death in the United States, according to the Centers for Disease
Control and Prevention (CDC).
The CDC
report that 29 million Americans currently live with the disease, and another
86 million have prediabetes.
Type 1 diabetes is characterized by the inability of
the pancreas to produce insulin. More specifically, the body's own
immune system stops recognizing the beta cells normally responsible for
producing insulin. Instead, it attacks and destroys them.
Without
insulin - which normally "tells" the body to start reducing the
levels of glucose - the blood sugar cannot enter the cells, where it is
normally transformed into energy. As a result, glucose gets stuck in the bloodstream,
leading to diabetes.
For
decades, scientists have been trying to find a way to replace these beta cells
- sometimes referred to as islet cells because they are located in an endocrine
area of the pancreas known as the islets of Langerhans.
Researchers
have attempted to replace destroyed beta cells with new ones using stem cells and
adult cells. Although the results have looked encouraging, they have yet to
succeed.
Now,
researchers from the CeMM Research Center for Molecular Medicine in Austria
seem to have found the missing link, giving hope of a cure for type 1 diabetes.
The role of alpha and beta cells
A team
of researchers - led by Stefan Kubicek, group leader at CeMM - examined the
role of a variety of approved drugs on alpha and beta cell transformation.
Their findings were published in the journal Cell.
In
addition to beta cells, alpha cells and three other types of cells form the
islets of Langerhans in the pancreas, where they are responsible for regulating
blood sugar levels.
Artemisinin can convert pancreatic alpha cells into
functional beta-like cells through enhanced GABA signaling.
Image credit: Cell Press/Stefan Kubicek, CeMM
Image credit: Cell Press/Stefan Kubicek, CeMM
While
beta cells help signal a reduction in blood sugar, alpha cells do the opposite,
by producing glucagon. However, alpha cells are flexible: they can transform
into beta cells.
In
cases of extreme beta cell depletion, alpha cells have been shown to turn into
insulin-producing beta cells, with the help of an epigenetic regulator known as
Arx.
Endocrine
cells need regulators to keep their identity. For instance, recent studies have shown that after the endocrine
cells have differentiated, in order for beta cells to maintain their identity,
the alpha cell epigenetic regulator Arx needs to be actively repressed.
"Arx
regulates many genes that are crucial for the functionality of an alpha
cell," says Kubicek. "Preceding work of our collaborator, Patrick
Collombat's team showed that a genetic knockout of Arx leads to a
transformation of alpha cells into beta cells."
So, at
this point, researchers knew that they needed Arx to transform the cells, but
they did not know whether there were other factors in the human organism that
influenced the process.
To
investigate this, Kubicek and team designed alpha and beta cell lines and
isolated them from their environment. They analyzed the cells and demonstrated
that a deprivation of Arx is enough to give a cell its beta identity, and no
other factors from the human body are required.
Malaria drug turns alpha cells into insulin-producing
cells
Now,
scientists were able to test the effects of a wide range of approved drugs on
cultured alpha cells using a specially designed, fully automated assay.
Researchers
found that artemisinins - a group of drugs commonly used to treat malaria - had the same effect as a loss in
Arx.
In other words, artemisinins transformed pancreatic alpha cells
into functional, insulin-producing beta-like cells.
"With
our study, we could show that artemisinins change the epigenetic program of
glucagon-producing alpha cells and induce profound alterations of their
biochemical function," explains Kubicek.
The way
this happens is through the activation of GABA receptors.
The effect of GABA in rodents and humans
GABA is a major neurotransmitter produced
by islet beta cells. It works as a transmitter within the islet cells, where it
regulates the secretion and function of the islet.
Artemisinins
reshape alpha cells by binding to a protein called gephyrin. This protein
activates the GABA receptors, which are like central switches of the cellular
signaling. At the end of a longer chain of biochemical reactions, GABA triggers
the production of insulin.
Kubicek's
study confirms previous mouse studies that have shown GABA to help transform
alpha cells into beta cells. One of these studies is led by Patrick Collombat
and is published in the same issue of Cell.
The
beneficial effects of artemisinins were shown not only in isolated cell line
experiments, but also in model organisms. Kubicek and team showed that the
malaria drug increased beta cell mass and improved homeostasis in zebrafish,
mice, and rats.
It is very likely that the same effect will happen in humans,
say the authors, because the molecular targets for artemisinins in fish,
rodents, and humans are very similar.
"Obviously, the long-term effect of artemisinins needs to be
tested. Especially the regenerative capacity of human alpha cells is yet
unknown. Furthermore, the new beta cells must be protected from the immune
system. But we are confident that the discovery of artemisinins and their mode
of action can form the foundation for a completely new therapy of type 1
diabetes."
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